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Abstract #3771

Simultaneous, trimodal MR-PET-EEG at 3T in humans: Glutamate drives energy consumption in the default mode network

Irene Neuner1,2,3, Jörg Mauler1, Ravichandran Rajkumar1,2,3, Ezequiel Farrher1, Elena Rota Kops1, Lutz Tellmann1, Jürgen Scheins1, Frank Boers1, Karl Josef Langen1,3,4, Hans Herzog1,2,3, and N. Jon Shah1,3,5

1Institute of Neuroscience and Medicine 4 (INM 4), Forschungszentrum Juelich GmbH, Juelich, Germany, 2Department of Psychiatry, Psychotherapy and Psychosomatics, RWTH Aachen University, Aachen, Germany, 3JARA-BRAIN, Translational Medicine, Aachen, Germany, 4Department of Nuclear Medicine, RWTH Aachen University, Aachen, Germany, 5Department of Neurology, RWTH Aachen University, Aachen, Germany

Within the scope of this explorative pilot trial we focus on the role of GABA and glutamate within the default mode network with regard to energy consumption. In one simultaneous session MR, FDG-PET and EEG data were recorded at a 3T hybrid MR-BrainPET scanner (Siemens, Germany) equipped with a 32 channel MR-compatible EEG system (Brain Products, Germany) in 11 healthy volunteers. The Pearson correlation showed a statistically significant positive correlation between glutamate ratio and mean CMRGlu in the DMN (r = 0.678, n = 11, p = 0.022) but none to GABA.

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