Abstract #3770

A novel, single scanning session approach to image rat brain activity applying simultaneous [18F]FDG-PET and BOLD-fMRI

Mario Amend¹, Tadashi Watabe², André Thielcke¹, Bernd J Pichler¹, and Hans F Wehrl¹

¹Department of Preclinical Imaging and Radiopharmacy, Werner Siemens Imaging Center, Eberhard Karls University, Tuebingen, Germany, ²Department of Nuclear Medicine and Tracer Kinetics, Osaka University Graduate School of Medicine, Osaka, Japan

Functional and metabolic processes during brain activity are still not fully understood. We established a novel protocol to image rat brain activation in a single scanning session, enabling optimal comparison of PET/fMRI data. Performing activation and baseline scans in one single scanning session is challenging due to the half-life (here [¹⁸F]FDG: 109.8 min) and decay time of PET-tracers. Applying [¹⁸F]FDG-PET and BOLD-fMRI, spatial and quantitative correlations but also mismatches between the glucose proportional PET and the fMRI activation data were found. Our results provide the basis for further studies of brain function and point towards the complementary nature of PET/MR.

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