A novel, single scanning session approach to image rat brain activity applying simultaneous [18F]FDG-PET and BOLD-fMRI
Mario Amend1, Tadashi Watabe2, André Thielcke1, Bernd J Pichler1, and Hans F Wehrl1
1Department of Preclinical Imaging and Radiopharmacy, Werner Siemens Imaging Center, Eberhard Karls University, Tuebingen, Germany, 2Department of Nuclear Medicine and Tracer Kinetics, Osaka University Graduate School of Medicine, Osaka, Japan
metabolic processes during brain activity are still not fully understood. We
established a novel protocol to image rat brain activation in a single scanning
session, enabling optimal comparison of PET/fMRI data. Performing activation
and baseline scans in one single scanning session is challenging due to the
half-life (here [18F]FDG: 109.8 min) and decay time of PET-tracers. Applying
[18F]FDG-PET and BOLD-fMRI, spatial
and quantitative correlations but also mismatches between the glucose
proportional PET and the fMRI activation data were found. Our results provide
the basis for further studies of brain function and point towards the
complementary nature of PET/MR.
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