Abstract #3769

Multimodal elucidation of rat brain function using BOLD-fMRI and CMRO2 [15O]O2-PET

Hans F Wehrl^1,2, Jun-ichiro Enmi¹, Mario Amend², Kazuhiro Koshino¹, Masako Kunimi¹, Takashi Temma¹, and Hidehiro Iida¹

¹Department of Investigative Radiology, National Cerebral and Cardiovascular Center Research Institute, Suita City, Osaka, Japan, ²Department of Preclinical Imaging and Radiopharmacy, Werner Siemens Imaging Center, Eberhard Karls University of Tuebingen, Tuebingen, Germany

The complex interplay of CMRO₂, CBF and CMRO₂ changes that constitute the BOLD effect are not fully unsterstood. Here we study rat brain activation using combined BOLD-fMRI and CMRO₂ proportional [¹⁵O]O₂-PET during the same anesthesia session. To our knowledge, such combined measurements have not been obtained before in small animals. We observed a spatial mismatch between the main activation centers as well as additional activated regions in the CMRO₂-PET, not present in BOLD-fMRI. However, statistical significances of activation sites were higher in BOLD-fMRI compared to [¹⁵O]O₂-PET. This work points towards a complementary nature of both methods in certain brain areas.

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