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Abstract #3769

Multimodal elucidation of rat brain function using BOLD-fMRI and CMRO2 [15O]O2-PET

Hans F Wehrl1,2, Jun-ichiro Enmi1, Mario Amend2, Kazuhiro Koshino1, Masako Kunimi1, Takashi Temma1, and Hidehiro Iida1

1Department of Investigative Radiology, National Cerebral and Cardiovascular Center Research Institute, Suita City, Osaka, Japan, 2Department of Preclinical Imaging and Radiopharmacy, Werner Siemens Imaging Center, Eberhard Karls University of Tuebingen, Tuebingen, Germany

The complex interplay of CMRO2, CBF and CMRO2 changes that constitute the BOLD effect are not fully unsterstood. Here we study rat brain activation using combined BOLD-fMRI and CMRO2 proportional [15O]O2-PET during the same anesthesia session. To our knowledge, such combined measurements have not been obtained before in small animals. We observed a spatial mismatch between the main activation centers as well as additional activated regions in the CMRO2-PET, not present in BOLD-fMRI. However, statistical significances of activation sites were higher in BOLD-fMRI compared to [15O]O2-PET. This work points towards a complementary nature of both methods in certain brain areas.

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