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Abstract #3781

Anesthesia increases water diffusion in wakefulness/sleep brain regions in the rat brain

Yoshifumi Abe1, Tomokazu Tsurugizawa1, and Denis Le Bihan1

1NeuroSpin, Commissariat à l’Energie Atomique-Saclay Center, Gif-sur-Yvette, France

Diffusion fMRI (DfMRI) has been shown to reflect neuronal activation more directly than BOLD fMRI, showing neuronal responses even when neurovascular coupling is abolished. We compared resting state ADC and BOLD fMRI time courses under different anesthesia conditions. While BOLD fMRI showed a widespread signal increase with isofluorane and a decrease with medetomidine, the ADC increased significantly with both agents in specific regions, notably in the wakefulness/sleep network. The amount of ADC increase was correlated with the dose of anesthetic agent, suggesting the suitability of DfMRI to investigate brain resting state or pharmacological challenges quantitatively and without vascular confounding effects.

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