Abstract #3782

Recruitment of Distinct Cortical and Subcortical Activations by Layer and Frequency Specific Optogenetic Stimulation in Primary Visual Cortex

Russell W Chan^1,2, Alex TL Leong^1,2, Patrick P Gao^1,2, Leon C Ho^1,2, Kevin K Tsia², and Ed X Wu^1,2

¹Laboratory of Biomedical Imaging and Signal Processing, The University of Hong Kong, Hong Kong, China, People's Republic of, ²Electrical and Electronic Engineering, The University of Hong Kong, Hong Kong, China, People's Republic of

Different layers in mammalian cortex have specific projections and circuit dynamics. However, how optogenetic stimulation frequencies at different infragranular layers contribute to widespread and large-scale cortical and subcortical activities remains largely unexplored. In this study, optogenetic fMRI is used to investigate layer and frequency dependent activities by stimulating excitatory neurons in different infragranular layers of visual cortex. Our results showed that layer and frequency specific optogenetic stimulation recruits distinct widespread and large-scale cortical and subcortical activations. Spatiotemporally varying optogenetic stimulation in combination with fMRI presents unique opportunities in studying the underlying mechanisms of long-range neural circuits and brain functional networks.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.