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Abstract #3784

Development of Carbon Nanotube Optrodes to Acquire LFP and BOLD Concurrently with Optogenetic Stimulation

Corey Cruttenden1, Jennifer M. Taylor2, Xiao-Hong Zhu2, Yi Zhang2, Hannes M. Wiesner2, Anders Asp3, Erin Larson3, Wilson Yu3, Rajesh Rajamani1, Mark Thomas3, Esther Krook-Magnuson3, and Wei Chen2

1Mechanical Engineering, University of Minnesota, Minneapolis, MN, United States, 2Center for Magnetic Resonance Research (CMRR), University of Minnesota, Minneapolis, MN, United States, 3Neuroscience, University of Minnesota, Minneapolis, MN, United States

Carbon nanotube optrodes are under development for simultaneous optogenetics, neural recording, and fMRI BOLD signal acquisition. First-generation devices demonstrate capability in combining optogenetic stimulation and neural recording in vivo, but in vitro MR-images reveal severe susceptibility artifacts generated by terminal silver leads. New devices utilize carbon fiber wires in place of silver. Initial in vitro images of the second-generation device show a dramatic reduction of image artifacts, indicating that BOLD signal should be obtainable around the optrodes. The new devices will enable the combination of the aforementioned techniques, providing a platform for novel brain investigations.

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