Abstract #3784

Development of Carbon Nanotube Optrodes to Acquire LFP and BOLD Concurrently with Optogenetic Stimulation

Corey Cruttenden¹, Jennifer M. Taylor², Xiao-Hong Zhu², Yi Zhang², Hannes M. Wiesner², Anders Asp³, Erin Larson³, Wilson Yu³, Rajesh Rajamani¹, Mark Thomas³, Esther Krook-Magnuson³, and Wei Chen²

¹Mechanical Engineering, University of Minnesota, Minneapolis, MN, United States, ²Center for Magnetic Resonance Research (CMRR), University of Minnesota, Minneapolis, MN, United States, ³Neuroscience, University of Minnesota, Minneapolis, MN, United States

Carbon nanotube optrodes are under development for simultaneous optogenetics, neural recording, and fMRI BOLD signal acquisition. First-generation devices demonstrate capability in combining optogenetic stimulation and neural recording in vivo, but in vitro MR-images reveal severe susceptibility artifacts generated by terminal silver leads. New devices utilize carbon fiber wires in place of silver. Initial in vitro images of the second-generation device show a dramatic reduction of image artifacts, indicating that BOLD signal should be obtainable around the optrodes. The new devices will enable the combination of the aforementioned techniques, providing a platform for novel brain investigations.

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