Abstract #3785

Concurrent 32-channel electrophysiological recording and fMRI in bilateral rat striatum

Saul Jaime^1,2, Hanbing Lu¹, Jose Cavazos^2,3, and Yihong Yang¹

¹Neuroimaging Research Branch, National Institute on Drug Abuse, NIH, Baltimore, MD, United States, ²Physiology, Uni. Texas Health Science Center-San Antonio, San Antonio, TX, United States, ³Neurology, Uni. Texas Health Science Center-San Antonio, San Antonio, TX, United States

Despite the high clinical and pre-clinical value of fMRI, its success depends on the identification of the underlying neurophysiological basis of the fMRI BOLD signal. In previously reported simultaneous electrophysiology and fMRI studies, experiments were limited by the poor spatial resolution or poor source localization of intra-cranial or surface EEG techniques employed to record neural activity. In order to overcome these limitations, we have developed a method that allows concurrent whole brain fMRI acquisition and 32-channel intra-cerebral electrophysiological recording in the rat brain.

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