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Abstract #3789

Increased activation of precuneus and posterior cingulate cortex in resting state fMRI in patients with functional movement disorders after undergoing a motor retraining program

Kwan-Jin Jung1, Sarah Mufti2, and Kathrin LaFaver2

1Radiology, University of Louisville, Louisville, KY, United States, 2Neurology, University of Louisville, Louisville, KY, United States

Functional movement disorders (FMD) can be significantly reduced with a one-week motor retraining program. Our study compared resting state fMRI before and after treatment of 6 FMD patients. We found increased activity in the posterior default mode network, specifically the precuneus and posterior cingulate cortex, in 4 out of 6 patients after treatment, which correlated with clinical improvement of motor symptoms. Our findings suggest that restoration of normal movements in FMD patients are accompanied by increased default mode network activation.

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