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Abstract #3790

Demonstration of brain tumor-related NVU in both task-based fMRI and resting state fMRI

Shruti Agarwal1, Noushin Yahyavi-Firouz-Abadi1, Haris I. Sair1, Raag Airan1, and Jay J. Pillai1

1Division of Neuroradiology, Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, United States

The phenomenon of neurovascular uncoupling (NVU) is a limitation of clinical fMRI, particularly in presurgical mapping. A previous study using task-based motor activation (tbfMRI) and breath hold cerebrovascular reactivity (BH CVR) mapping demonstrated that BH CVR was capable of detecting NVU in low-grade perirolandic tumors. In this study we demonstrated the effect of NVU on resting state fMRI (rsfMRI) data within the sensorimotor network through comparison to both BH CVR and task-based fMRI data.

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