Abstract #3790

Demonstration of brain tumor-related NVU in both task-based fMRI and resting state fMRI

Shruti Agarwal¹, Noushin Yahyavi-Firouz-Abadi¹, Haris I. Sair¹, Raag Airan¹, and Jay J. Pillai¹

¹Division of Neuroradiology, Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, United States

The phenomenon of neurovascular uncoupling (NVU) is a limitation of clinical fMRI, particularly in presurgical mapping. A previous study using task-based motor activation (tbfMRI) and breath hold cerebrovascular reactivity (BH CVR) mapping demonstrated that BH CVR was capable of detecting NVU in low-grade perirolandic tumors. In this study we demonstrated the effect of NVU on resting state fMRI (rsfMRI) data within the sensorimotor network through comparison to both BH CVR and task-based fMRI data.

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