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Abstract #3792

Functional brain changes in breachers following a blast-overpressure: an acute longitudinal assessment with MRI

Fatima Nasrallah1,2, Trina Kok1, Mary Stephenson1, Jiesen Wang3, Alexandre Schaefer3, You Jin1, Benjamin Thomas1, Pamela Pun Boon Li4, Melissa Teo Ai Ling4, Julie Yeo Su Li4, Jia Lu4, John Tottman1, and David Townsend5

1Clinical Imaging Research Centre, NUS/A*STAR, Singapore, Singapore, 2Queensland Brain Institute, Queensland, Australia, 3Clinical Imaging Research Centre, NUS, Singapore, Singapore, 4Defense Singapore Organisation, DSO, Singapore, Singapore, 5clinical Imaging Research Centre, NUS/A*STAR, Singapore, Singapore

Blast injury is one of the most common types of mild traumatic brain injury. In this work we have investigated the longitudinal changes induced by a blast-overpressure injury in breacher trainers using resting state functional connectivity MRI. We show that reductions in connectivity in the Thalamic and Cerebellar regions at Day 1 following a blast are regained and increased 1 month post blast.

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