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Abstract #3793

Parkinson’s disease laterality impact onto the default mode network deactivation by the audio-motor transformation

Oleksii Omelchenko1, Zinayida Rozhkova2, and Iryna Karaban3

1Human and Animal Physiology, Taras Shevchenko National University of Kyiv, Kyiv, Ukraine, 2Radiology, Medical Clinic BORIS, Kyiv, Ukraine, 3Department of extrapyramidal disorders, D. F. Chebotarev Institute of Herontology, Kyiv, Ukraine

Asymmetry of motor symptoms is considered a crucial criterion for PD and influence hemisphere-associated cognitive functions. DMN was shown to loose it’s functional connectivity in PD. We hypothesized that AMT play important role in switching DMN to task-related deactivation state. AMT exploration for PD laterality specific DMN connectivity analysis during movements was done. AMT and movement execution in PD evokes activation auditory cortex, SMN and pC. In PD patients DMN deactivates exceptionally at the period of motor activity. pC participates as a DMN ‘hub’ and DMN deactivation ‘switching’ trigger during AMT. PD symtoms lateralization play important role in DMN functioning.

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