Abstract #3795

Local and Distant Functional Connectivity Density Alteration in Primary Open-angle Glaucoma: A Resting-state functional MRI Study

Zhenyu Liu¹ and Ting Li²

¹Key Laboratory of Molecular Imaging, Institute of Automation, Beijing, China, People's Republic of, ²Beijing Tongren Hospital, Beijing, China, People's Republic of

To measure functional connectivity density maps were applied with resting-state functional MRI. Twenty-one patients and twenty-two age- and gender-matched healthy controls were evaluated by 3T MRI using resting-state blood oxygenation level dependent imaging. POAG patients showed decreased FCD values in visual cortices and increased FCD values of DMN components. This study demonstrates POAG can induce reorganization of brain function in multiple brain regions, including visual cortices and DMN.

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