Abstract #3796

Altered Amplitude of Low-Frequency Fluctuation and functional connectivity in High Myopia: A Resting-State fMRI Study

Xue-wei Zhang^1,2, Wei-hong Zhang², and Qin Long³

¹Department of Interventional Radiology, China Meitan General Hospital, Beijing, China, People's Republic of, ²Department of Radiology, Peking Union Medical College Hospital, Beijing, China, People's Republic of, ³Department of Ophthalmology, Peking Union Medical College Hospital, Beijing, China, People's Republic of

High myopia (HM) can result in serious vision problems. To date, the pathophysiologic mechanism remains unknown. The authors tried to explore the potential locations which involved in the brain abnormalities of HM patients, through observing altered ALFF of different bands and functional connectivity of the brain by rs-fMRI. The results showed that, not only visual cortex but also multiple brain regions were noted to have abnormal changes in the brain of HM patients. In conclusion, the findings indicated that high myopia affects many functional networks, and different bands of ALFF may provide a new way to explore the underlying mechanism.

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