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Abstract #3802

Multi Voxel Pattern Analysis (MVPA) classification reveals distributed neural presentations of specific finger movement sequences in the human striatum: a task-based functional MRI study.

Kasper Winther Andersen1, Kristoffer H Madsen1, Tim B Dyrby1, and Hartwig R Siebner1,2

1Danish Research Centre for Magnetic Resonance, Centre for Functional and Diagnostic Imaging and Research, Copenhagen University Hospital Hvidovre, Denmark, Copenhagen, Denmark, 2Department of Neurology, Copenhagen University Hospital Bispebjerg, Copenhagen, Denmark

The basal ganglia is a group of subcortical nuclei, which receives connections from almost the entire cerebral cortex. Here, we investigated the involvement of the striatum, which is the input structure of the basal ganglia, in a sequential finger movement task using fMRI. Sixteen healthy controls performed finger sequences with different complexities. Multi Voxel Pattern Analysis was used to discriminate the distributed signal in striatum and cortex. We found that the distributed signals in contra-lateral striatum are discriminative of the finger sequence performed, which points to a significant role of the basal ganglia in the control of finger sequences.

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