Abstract #3801

Data-driven model for evaluation of cerebrovascular-reserve measurement with hypercapnia BOLD

Lenka Vondráčková^1,2, Pawel Krukowski³, Johannes Gerber³, Jennifer Linn³, Jan Kybic², and Jan Petr¹

¹Institute of Radiopharmaceutical Cancer Research, Helmholtz-Zentrum Dresden-Rossendorf, Dresden, Germany, ²Center for Machine Perception, Faculty of Electrical Engineering, Czech Technical University in Prague, Prague, Czech Republic, ³Department, University Hospital Carl Gustav Carus, Dresden, Germany

Hypercapnia BOLD with the breath-holding task is a technically easier and more clinically available alternative to cerebrovascular reserve (CVR) mapping than administration of CO₂ enriched air using an air-tight mask. The disadvantage is complicated data evaluation in case the subject does not adhere to the breathing protocol completely. Here, a data-driven approach for evaluation is presented that is more robust to protocol deviations and produces a reasonable CVR map in most cases where the standard model-driven approach fails. This is demonstrated on randomized evaluation of CVR maps of a group of 86 subjects with stenosis or vessel occlusion.

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