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Abstract #3807

Effects of Hyperglycemia and Hyperinsulinemia on Amplitude of Low Frequency Fluctuations in Medial Frontal and Posterior Cingulate Cortices in Healthy Non-Diabetic Subjects

Nicolas R. Bolo1,2, Alan M. Jacobson3, Brandon Hager1, Gail Musen2,4, Matcheri Keshavan1,2, and Donald C. Simonson5,6

1Psychiatry, Beth Israel Deaconess Medical Center, Boston, MA, United States, 2Psychiatry, Harvard Medical School, Boston, MA, United States, 3Research Institute, Winthrop University Hospital, Mineola, NY, United States, 4Research Division, Joslin Diabetes Center, Boston, MA, United States, 5Division of Endocrinology, Brigham and Women's Hospital, Boston, MA, United States, 6Harvard Medical School, Boston, MA, United States

Our goal is to elucidate the independent effects of hyperglycemia and hyperinsulinemia on brain function. We measured whole-brain amplitude of low frequency fluctuations (ALFF) in slow-band 5 (SB5: 0.01-0.027Hz) and slow-band 4 (SB4: 0.027-0.073Hz) in 10 healthy non-diabetic subjects using resting state fMRI during fasting baseline euglycemia (EU), hyperglycemia (HG) and euglycemic hyperinsulinemia (EU-HI). SB5 fractional ALFF was decreased in the left medial frontal gyrus and right posterior cingulate/cuneus/precuneus cortices during HG, but not during EU-HI, relative to EU. Our findings may help understand brain functional adaptations to chronic hyperglycemia in diabetes, and their implications for comorbid neuropsychiatric complications.

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