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Abstract #3808

ECG-derived respiratory signal for physiological noise correction in simultaneous EEG-fMRI for enhanced mapping of epileptic activity

Rodolfo Abreu1, Sandro Nunes1, Alberto Leal2, and Patrícia Figueiredo1

1ISR-Lisboa/LARSyS and Department of Bioengineering, Instituto Superior Técnico, Universidade de Lisboa, Lisboa, Portugal, 2Department of Neurophysiology, Centro Hospitalar Psiquiátrico de Lisboa, Lisboa, Portugal

We propose a physiological noise model where respiratory-induced BOLD signal fluctuations were extracted from a surrogate of the respiratory signal estimated by Empirical Mode Decomposition. We optimized this model on a subject-specific basis, and evaluate its impact EEG-correlated fMRI mapping of epileptic networks, by comparing the epileptic maps obtained with and without physiological noise correction. This assessment was performed in terms of specificity and sensitivity, having been obtained not only substantial improvements for both measures, but also plausible and patients' semiology concordant epileptic networks.

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