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Abstract #3838

Detection of Reduction in Liver Stiffness as a Result of Weight Loss Surgery using MR Elastography

Curtis N. Wiens1, Alan B. McMillan1, Nathan S. Artz1,2, Rashmi Agni3, Michael Peterson4, Nikolaus Szeverenyi5, William Haufe5, Catherine Hooker5, Luke Funk6, Jacob Greenberg6, Guilherme M. Campos7, Santiago Horgan8, Garth Jacobsen8, Tanya Wolfson9, Claude Sirlin5, and Scott B. Reeder1,10,11,12,13

1Radiology, University of Wisconsin, Madison, WI, United States, 2Diagnostic Imaging, St. Jude Children's Research Hospital, Memphis, TN, United States, 3Pathology, University of Wisconsin, Madison, WI, United States, 4Tacoma General Pathology, Tacoma, WA, United States, 5Radiology, University of California, San Diego, CA, United States, 6Surgery, University of Wisconsin, Madison, WI, United States, 7Virginia Commonwealth University, Surgery, VA, United States, 8Surgery, University of California, San Diego, CA, United States, 9Computational and Applied Statistics Laboratory, University of California, San Diego, CA, United States, 10Medical Physics, University of Wisconsin, Madison, WI, United States, 11Biomedical Engineering, University of Wisconsin, Madison, WI, United States, 12Medicine, University of Wisconsin, Madison, WI, United States, 13Emergency Medicine, University of Wisconsin, Madison, WI, United States

This study tracked changes in liver stiffness in morbidly obese patients undergoing bariatric surgery. 22 patients undergoing bariatric surgery were recruited for MRI studies including MR elastography (MRE) at 2 time points: 1-2 days prior to and 6 months after bariatric surgery. Changes in liver stiffness as measured by MRE were compared to intraoperative biopsies which were performed to assess relevant histological features (steatosis, inflammation and fibrosis) and their relation to liver stiffness. Follow-up measurement of liver stiffness 6 months after bariatric surgery showed statistically significant reductions in liver stiffness. Patients with biopsy confirmed liver fibrosis, inflammation and features of NASH exhibited the largest reductions in liver stiffness.

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