Abstract #3841

Proton-density fat-fraction quantification of the liver in the presence of ferumoxytol at 1.5T and 3T

Camilo A Campo¹, Diego Hernando¹, Tilman B Schubert¹, Utaroh Motosugi^1,2, Samir D Sharma¹, Shane A Wells¹, and Scott B Reeder^1,3,4,5,6

¹Radiology, University of Wisconsin-Madison, Madison, WI, United States, ²Radiology, University of Yamanashi, Yamanashi, Japan, ³Medical Physics, University of Wisconsin-Madison, Madison, WI, United States, ⁴Biomedical Engineering, University of Wisconsin-Madison, Madison, WI, United States, ⁵Medicine, University of Wisconsin-Madison, Madison, WI, United States, ⁶Emergency Medicine, University of Wisconsin-Madison, Madison, WI, United States

This study evaluated the accuracy of liver proton-density fat-fraction (PDFF) quantification in the presence of ferumoxytol. Seven healthy subjects underwent MRI scans immediately before injection of ferumoxytol and one day after injection. Our results indicate that confounder-corrected chemical shift-encoded MRI PDFF estimates exhibit a small but significant bias in the presence of ferumoxytol. This bias could be due to differential shortening in the T2* of water and fat signals. Therefore, investigators attempting to create human models of iron and fat within the liver by administering ferumoxytol to patients with fatty liver should be aware of this potential source of bias.

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