Abstract #3842

Impaired hepatic arterial buffer response in a rodent model of chronic liver disease: assessment using caval subtraction phase-contrast MRI at 9.4T

Manil Chouhan¹, Alan Bainbridge², Nathan Davies³, Simon Walker-Samuel⁴, Shonit Punwani¹, Mark Lythgoe⁴, Rajeshwar Mookerjee³, and Stuart Taylor¹

¹UCL Centre for Medical Imaging, University College London, London, United Kingdom, ²Department of Medical Physics, University College London Hospitals NHS Trust, London, United Kingdom, ³UCL Institute for Liver and Digestive Health, University College London, London, United Kingdom, ⁴UCL Centre for Advanced Biomedical Imaging, University College London, London, United Kingdom

Total liver blood flow (TLBF) is closely regulated in health so that reductions in portal venous (PV) flow are buffered by compensatory rises in hepatic arterial (HA) flow. In this study we use caval subtraction phase-contrast MRI to estimate TLBF and HA flow in cirrhotic rats and demonstrate an impaired HA buffer response after administering terlipressin, a vasopressin analogue used clinically used to reduce PV flow in portal hypertension.

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