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Abstract #3842

Impaired hepatic arterial buffer response in a rodent model of chronic liver disease: assessment using caval subtraction phase-contrast MRI at 9.4T

Manil Chouhan1, Alan Bainbridge2, Nathan Davies3, Simon Walker-Samuel4, Shonit Punwani1, Mark Lythgoe4, Rajeshwar Mookerjee3, and Stuart Taylor1

1UCL Centre for Medical Imaging, University College London, London, United Kingdom, 2Department of Medical Physics, University College London Hospitals NHS Trust, London, United Kingdom, 3UCL Institute for Liver and Digestive Health, University College London, London, United Kingdom, 4UCL Centre for Advanced Biomedical Imaging, University College London, London, United Kingdom

Total liver blood flow (TLBF) is closely regulated in health so that reductions in portal venous (PV) flow are buffered by compensatory rises in hepatic arterial (HA) flow. In this study we use caval subtraction phase-contrast MRI to estimate TLBF and HA flow in cirrhotic rats and demonstrate an impaired HA buffer response after administering terlipressin, a vasopressin analogue used clinically used to reduce PV flow in portal hypertension.

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