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Abstract #3843

Effect of choosing an in-phase vs. a default echo time in 2D MR elastography to estimate hepatic stiffness

Kang Wang1, William Haufe1, Nikolaus Szeverenyi1, Alexandra Schlein 1, Tanya Wolfson 2, Michael S. Middleton1, Jeffrey Schwimmer3, Kimberley Newton3, Cynthia Behling3, Janis Durelle3, Melissa Paiz3, Jorge Angeles3, Len Lazaro4, Diana De La Pena4, Carolyn Hernandez4, Rohit Loomba 4, Meng Yin5, Kevin Glaser5, Richard Ehman5, and Claude Sirlin1

1Liver Imaging Group, Department of Radiology, University of California, San Diego, School of Medicine, San Diego, CA, United States, 2Computational and Applied Statistics Laboratory, University of California, San Diego, San Diego, CA, United States, 3Department of Pediatric, University of California, San Diego, San Diego, CA, United States, 4NAFLD Translational Research Unit, Division of Gastroenterology, University of California, San Diego, San Diego, CA, United States, 5Departments of Radiology, Mayo Clinic, Rochester, MN, United States

To investigate the effect of different echo times (TE) in 2D MR elastography (2D MRE) to estimate hepatic stiffness, two 2D MRE scans were acquired in 50 patients using a 3T GE scanner, one with a default TE value of 20.1 ms (default-TE), and with a nearest in-phase TE value of 20.6 ms (IP-TE). Wave-image quality of each scan was measured quantitatively by ROI size. We demonstrated that 2D MRE with an in-phase TE provides slightly higher wave-image quality in patients with high PDFF, and potentially may be advantageous for fibrosis assessment in NAFLD.

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