Abstract #3845

Standardized approach for region-of-interest-based measurements of proton-density fat-fraction and R2* in the liver

Camilo A Campo¹, Diego Hernando¹, Candice Bookwalter^1,2, Tilman B Schubert¹, and Scott B Reeder^1,3,4,5,6

¹Radiology, University of Wisconsin-Madison, Madison, WI, United States, ²Radiology, Mayo Clinic, Rochester, MN, United States, ³Medical Physics, University of Wisconsin-Madison, Madison, WI, United States, ⁴Biomedical Engineering, University of Wisconsin-Madison, Madison, WI, United States, ⁵Medicine, University of Wisconsin-Madison, Madison, WI, United States, ⁶Emergency Medicine, University of Wisconsin-Madison, Madison, WI, United States

This study evaluated the reproducibility of different region-of-interest (ROI) sampling methods for MRI-based proton-density fat-fraction (PDFF) and R2* (1/T2*) measurements in the liver. 53 patient liver MRI datasets were retrospectively analyzed using ROI sampling methods that have been previously reported. Patients were not suspected of having hepatic steatosis or liver iron overload. Our results demonstrate improved measurement repeatability when the sampling area of the liver is increased by using multiple, large ROIs. Therefore, ROI-based measurements of liver PDFF and R2* should strive to sample the largest possible area of liver by using ROIs that are large in size and number.

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