Abstract #3846

R2* of liver fat and water compared to proton density fat fraction estimated by 1H MRS

Gavin Hamilton¹, Alexandra N Schlein¹, Adrija Mamidipalli¹, Michael S Middleton¹, Rohit Loomba², and Claude B Sirlin¹

¹Department of Radiology, University of California, San Diego, San Diego, CA, United States, ²Department of Medicine, University of California, San Diego, San Diego, CA, United States

MRI based methods of estimating hepatic proton density fat fraction (PDFF) measure only one R2* value, as the R2* of fat and water are assumed to be identical. MRS can estimate the R2* of both fat and water. Liver MRS spectra were fitted with constraints derived from those used in MRI, and water R2* and fat R2*^eff (the effective fat R2* that would be measured by MRI) were compared to PDFF. We found that water R2* was independent of PDFF, while fat R2*^eff was weakly and inversely correlated with PDFF.

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