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Abstract #3847

The Feasibility Study of Liver Cirrhosis Stage Using Quantitative 3D Whole-Liver T1ρ Mapping at 3.0T

Xin Chen1, Weibo Chen2,3, Guangbin Wang4, Shanshan Wang4, Tao Gong1, and Sai Shao1

1Shandong University, Jinan, China, People's Republic of, 2Shanghai Key Laboratory of Magnetic Resonance and Department of Physics, East China Normal University, Shanghai, China, Shanghai, China, People's Republic of, 3Philips Healthcare, shanghai, China, Shanghai, China, People's Republic of, 4Shangdong Medical Imaging Research Institute, Jinan, China, People's Republic of

Liver cirrhosis is an abnormal liver condition that the liver would repair it through the deposition of collagen, proteoglycans, and other macromolecules in the extracellular matrix [1]. The risk of liver cancer is greatly increased once cirrhosis develops. A non-invasive method that can objectively and simply assessment and grade the liver fibrosis is clinically required. T1ρ relaxation time has been proven to relevant with the macromolecular composition and proton exchange of tissues[2]. It may play as a non-invasive biomarker to investigate liver fibrosis. The first whole-liver study was carried out on 1.5T MR Scanner [3]. The purpose of our study was to implement the T1ρ method with whole-liver coverage that is breathing-hold free, and to initially apply the method to evaluate severity of whole-liver cirrhosis non-invasively at 3.0T.

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