Abstract #3850

THE EVALUATION OF PORTAL HYPERTENSION USING QUANTITATIVE MAGNETIC RESONANCE IMAGING (MRI)

Eleanor F Cox¹, Naaventhan Palaniyappan², Andrew Austin³, Richard O'Neill⁴, Greg Ramjas⁴, Simon Travis⁴, Hilary White⁴, Rajeev Singh³, Peter Thurley³, Indra Neil Guha², Guruprasad Padur Aithal², and Susan T Francis¹

¹SPMIC, School of Physics & Astronomy, University of Nottingham, Nottingham, United Kingdom, ²NIHR Nottingham Digestive Diseases Biomedical Research Unit, Nottingham University Hospitals NHS Trust and University of Nottingham, Nottingham, United Kingdom, ³Royal Derby Hospital, Derby, United Kingdom, ⁴Department of Radiology, Nottingham University Hospitals NHS Trust, Nottingham, United Kingdom

The hepatic venous pressure gradient (HVPG) is the only validated measure to assess portal pressure but this is invasive and not widely available. Here, we use non-invasive MR parameters as a surrogate for portal pressure. Longitudinal relaxation time (T1) measures of the liver and spleen, phase contrast measures of splanchnic and collateral flow, and ASL measures of perfusion are correlated against HVPG measures in 30 patients. Liver tissue T1 is shown to be positively correlated with HVPG (p<0.001). Combining T1 measures with splenic artery velocity using a simple linear model, it is shown that HVPG can be non-invasively assessed.

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