Abstract #3852

Comparison of R2* of liver water and fat using 1H MRS

Gavin Hamilton¹, Alexandra N Schlein¹, Adrija Mamidipalli¹, Michael S Middleton¹, Rohit Loomba², and Claude B Sirlin¹

¹Department of Radiology, University of California, San Diego, San Diego, CA, United States, ²Department of Medicine, University of California, San Diego, San Diego, CA, United States

To estimate hepatic proton density fat fraction (PDFF), MRI techniques acquire multi-echo, gradient-echo images, assuming the R2* of fat and water to be identical. Liver MRS spectra were fitted with constraints derived from those used in MRI to examine this assumption. We compared fat R2*^eff (the effective fat R2* that would be measured by MRI) with water R2* and found that water R2* and fat R2*^eff were correlated. There was no significant difference between water R2* and fat R2*^eff, supporting the assumption that when measuring PDFF using MRI, fat and water R2* can be treated as identical.

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