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Abstract #3852

Comparison of R2* of liver water and fat using 1H MRS

Gavin Hamilton1, Alexandra N Schlein1, Adrija Mamidipalli1, Michael S Middleton1, Rohit Loomba2, and Claude B Sirlin1

1Department of Radiology, University of California, San Diego, San Diego, CA, United States, 2Department of Medicine, University of California, San Diego, San Diego, CA, United States

To estimate hepatic proton density fat fraction (PDFF), MRI techniques acquire multi-echo, gradient-echo images, assuming the R2* of fat and water to be identical. Liver MRS spectra were fitted with constraints derived from those used in MRI to examine this assumption. We compared fat R2*eff (the effective fat R2* that would be measured by MRI) with water R2* and found that water R2* and fat R2*eff were correlated. There was no significant difference between water R2* and fat R2*eff, supporting the assumption that when measuring PDFF using MRI, fat and water R2* can be treated as identical.

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