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Abstract #3857

Assessment of fibrotic liver using T1rho mapping: a rat model study

Qihua Yang1, Taihui Yu1, Hui Zhang2, Hua Guo2, Yingjie Mei3, Ziliang Cheng1, Jingwen Huang1, and Biling Liang1

1Radiology Dept, Sun Yat-sen Memorial Hospital, Guangzhou, China, People's Republic of, 2Center for Biomedical Imaging Research, Department of Biomedical Engineering, School of Medicine, Tsinghua University, Beijing, China, People's Republic of, 3Philips Healthcare, Guangzhou, China, People's Republic of

To find out the relationship among T1rho, liver fibrosis stages and liver function, MRI including T1rho sequence was performed in 32 CCl4 induced liver fibrosis SD rat models and 12 SD rats of control group. Laboratory test related to liver function were done before execution and liver was taken out for pathology evaluation. Liver fibrosis was staged according to staging systems for rodents. Results showed that T1rho could be used to diagnose early liver fibrosis (>F2) and correlation was significant between T1rho values and both liver fibrosis stage and blood serum parameters.

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