Abstract #3856

Assessment of liver fibrosis by MRI tagging of cardiac-induced motion: preliminary results

Leonie Petitclerc^1,2, Guillaume Gilbert^2,3,4, Claire Wartelle-Bladou⁵, Giada Sebastiani⁶, Bich Nguyen^7,8, and An Tang^1,2,4

¹Centre de recherche du Centre hospitalier de l'Universite de Montreal, Montreal, QC, Canada, ²Department of Radiology, Radio-Oncology and Nuclear Medicine, Universite de Montreal, Montreal, QC, Canada, ³Philips Healthcare Canada, Montreal, QC, Canada, ⁴Centre hospitalier de l'Universite de Montreal, Montreal, QC, Canada, ⁵Department of Gastroenterology and Hepatology, Universite de Montreal, Montreal, QC, Canada, ⁶Department of Medicine, Division of Gastroenterology, McGill University Health Centre, Montreal, QC, Canada, ⁷Department of Pathology, Centre hospitalier de l'Universite de Montreal, Montreal, QC, Canada, ⁸Department of Pathology and Cellular Biology, Universite de Montreal, Montreal, QC, Canada

Elastography for the staging of liver fibrosis is optimized for the right liver and requires additional hardware. Using MRI tagging, the displacement and strain of liver tissue induced by cardiac motion was quantified with the Harmonic Phase (HARP) method. Of the four schemes tested for the extraction of a single measure of strain, one was especially promising, as it showed high correlation with fibrosis stages (Spearman’s ρ=-0.913), as well as a significant p-value for dichotomized diagnosis of ≥F3 fibrosis (p=0.03). These preliminary results suggest that strain measurements could be used as a diagnostic tool for the staging of liver fibrosis.

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