Abstract #3859

Improving Liver Iron Estimates with a Muscle-based Proton Density Estimate

Eamon K Doyle, MS¹, Andrew Powell, MD^2,3, and John C Wood, MD, PhD^4,5

¹Biomedical Engineering, University of Southern California, Sierra Madre, CA, United States, ²Cardiology, Boston Children's Hospital, Boston, MA, United States, ³Pediatrics, Harvard School of Medicine, Boston, MA, United States, ⁴Cardiology, Children's Hospital of Los Angeles, Los Angeles, CA, United States, ⁵Biomedical Engineering, University of Southern California, Los Angeles, CA, United States

CPMG-based R2 (1/T2) estimates are traditionally insensitive to tissue iron load. We show that the application of a T1-corrected, skeletal muscle-based proton density constraint increases the sensitivity of R2 for iron quantitation in phantoms and human subjects. This method leads to a fundamentally different R2-LIC (liver iron concentration) calibration curve than has previously been applied to CPMG fit data.

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