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Abstract #3860

Accelerated Segmented Diffusion-Weighted Prostate Imaging for Higher Resolution, Better Geometric Fidelity, and Multi-b Perfusion Quantification

Pelin Aksit Ciris1, Jr-yuan George Chiou2, Andriy Fedorov2, Hualei Shelley Zhang2, Clare Mary Tempany-Afdhal2, Bruno Madore2, and Stephan Ernst Maier2,3

1Department of Biomedical Engineering, Akdeniz University, Antalya, Turkey, 2Department of Radiology, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, United States, 3Department of Radiology, University of Gothenburg, Gothenburg, Sweden

An accelerated multi-shot diffusion imaging sequence and reconstruction scheme was developed for prostate imaging, allowing improvements in spatial resolution, geometric-fidelity and b-factor coverage to be achieved within a short scan time. Two-fold improvement in spatial resolution and three-fold improvement in geometric fidelity were obtained as compared to single-shot EPI, in twelve prostate cancer patients. In contrast to the standard protocol, which involves separate scans with high (b=1400 and 0 s/mm2) and intermediate (b=500 and 0 s/mm2) diffusion weighting, the proposed accelerated protocol yielded an additional 8 b-factors in half the scan time (5 min 43 s vs. 11 min 48 s).

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