Abstract #3860

Accelerated Segmented Diffusion-Weighted Prostate Imaging for Higher Resolution, Better Geometric Fidelity, and Multi-b Perfusion Quantification

Pelin Aksit Ciris¹, Jr-yuan George Chiou², Andriy Fedorov², Hualei Shelley Zhang², Clare Mary Tempany-Afdhal², Bruno Madore², and Stephan Ernst Maier^2,3

¹Department of Biomedical Engineering, Akdeniz University, Antalya, Turkey, ²Department of Radiology, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, United States, ³Department of Radiology, University of Gothenburg, Gothenburg, Sweden

An accelerated multi-shot diffusion imaging sequence and reconstruction scheme was developed for prostate imaging, allowing improvements in spatial resolution, geometric-fidelity and b-factor coverage to be achieved within a short scan time. Two-fold improvement in spatial resolution and three-fold improvement in geometric fidelity were obtained as compared to single-shot EPI, in twelve prostate cancer patients. In contrast to the standard protocol, which involves separate scans with high (b=1400 and 0 s/mm²) and intermediate (b=500 and 0 s/mm²) diffusion weighting, the proposed accelerated protocol yielded an additional 8 b-factors in half the scan time (5 min 43 s vs. 11 min 48 s).

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