Juan C. Camacho1,2, Nima Kokabi1, Peter A. Harri1, Tracy E. Powell2, and Sherif G. Nour1,2
1Radiology and Imaging Sciences, Emory University School of Medicine, Atlanta, GA, United States, 2Interventional MRI Program, Emory University Hospital, Atlanta, GA, United States
The study objective is to investigate
magnetic resonance Apparent Diffusion Coefficient Quantification (ADC) in prostate
lesions and to correlate the values with the results of MRI-guided prostate targeted
sampling. A prospective cohort of patients presenting
with persistently elevated or rising serum prostate specific antigen (PSA) and
at least one lesion suspicious for prostate cancer that underwent MRI guided
targeted biopsy was evaluated. Thirty-five consecutive
patients were recruited presenting with 179 suspicious lesions. ROC curve analysis demonstrates that ADC predicts the
presence of malignancy and allows grade stratification and therefore, behaves
as a non-invasive imaging biomarker.
