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Abstract #3865

MR Apparent Diffusion Coefficient (ADC) Quantification is an Imaging Biomarker Predicting Gleason Score grade in Patients with Prostate Cancer undergoing MRI-guided prostate biopsy

Juan C. Camacho1,2, Nima Kokabi1, Peter A. Harri1, Tracy E. Powell2, and Sherif G. Nour1,2

1Radiology and Imaging Sciences, Emory University School of Medicine, Atlanta, GA, United States, 2Interventional MRI Program, Emory University Hospital, Atlanta, GA, United States

The study objective is to investigate magnetic resonance Apparent Diffusion Coefficient Quantification (ADC) in prostate lesions and to correlate the values with the results of MRI-guided prostate targeted sampling. A prospective cohort of patients presenting with persistently elevated or rising serum prostate specific antigen (PSA) and at least one lesion suspicious for prostate cancer that underwent MRI guided targeted biopsy was evaluated. Thirty-five consecutive patients were recruited presenting with 179 suspicious lesions. ROC curve analysis demonstrates that ADC predicts the presence of malignancy and allows grade stratification and therefore, behaves as a non-invasive imaging biomarker.

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