Rossella Canese1, Davide Fierro2, Francesca Romana Giura2, Gianmauro Palombelli1, Elena Lucia Indino2, Vincenzo Salvo2, Carlo Catalano2, and Valeria Panebianco2
1Cell Biology and Neurosciences, Istituto Superiore di Sanita', Rome, Italy, 2Radiological Sciences, Oncology and Pathology, Sapienza University of Rome, Rome, Italy
To date, most clinical DW-MRI studies have employed a monoexponential
model for data analysis, which produces the ADC parameter for assessing
diffusion characteristics whose value correlate with Gleason scores in prostate
cancer. The intravoxel incoherent motion (IVIM) model introduce a fast
diffusing component in the signal due to perfusion effects, but the application
of this method is not yet widespread included in clinical practice. This study was aimed at measuring the water diffusion in tissue separating
and estimating the perfusion component
by adopting a simple protocol easy to be implemented in clinical practice and
evaluating its diagnostic performance
