Abstract #3877

19F ZTE MR Imaging of 19F labeled calcium phosphate cement at 11.7T

Weiqiang Dou¹, Simone Mastrogiacomo², Olga Koshkina³, Andor Veltien¹, Mangala Srinivas³, X. Frank Walboomers², and Arend Heerschap¹

¹Radiology, Radboud University Medical Centre, Nijmegen, Netherlands, ²Biomaterials, Radboud University Medical Centre, Nijmegen, Netherlands, ³Tumor Immunology, Radboud University Medical Centre, Nijmegen, Netherlands

To enhance the MR image contrast of calcium phosphate cement (CPC) to bone, it was tagged with a ¹⁹F loaded nanoparticle as a contrast agent. ¹⁹F zero echo time (ZTE) MRI was applied for the first time for ¹⁹F imaging of this CPC in bone at 11.7T. The T₁ and T₂^* relaxation times of the ¹⁹F nanoparticles were measured for optimal settings of ¹⁹F ZTE MRI. We demonstrate overlaid ¹H+¹⁹F ZTE images of in vitro and ex vivo CPC/bone samples with hyperintense ¹⁹F signals allowing a qualitative and quantitative evaluation of these samples.

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