Abstract #3899

Diffusional Kurtosis Imaging of Kidneys in Children with Chronic Kidney Disease: Initial Experience

Yang Wen¹, Yun Peng¹, Dan Dan Zheng², Zhi Chen³, Guang Heng Yin¹, Yan Qiu Lv¹, Chen Xu¹, and Yang Fan²

¹Department of Radiology, Beijing Children’s Hospital Affiliated to Capital Medical University, Beijing, China, People's Republic of, ²GE Healthcare, MR Research China, Beijing, China, People's Republic of, ³Department of Nephrology, Beijing Children’s Hospital Affiliated to Capital Medical University, Beijing, China, People's Republic of

To evaluate the feasibility of DKI in assessment of renal functions in children with chronic kidney disease (CKD). Materials and Methods: This study was IRB approved and informed consent was obtained. Fifteen pediatric patients with CKD and nine children without renal diseases underwent DKI of kidneys. Maps of fractional anisotropy (FA), mean diffusivity (MD), mean kurtosis (MK), radial kurtosis (K_⊥) and axial kurtosis (K_//) were produced. Results: There is a significant difference of kurtosis metrics and FA of renal medulla compared to those of renal cortex in both the control group and CKD group. FA, MD, K_⊥ and MK values of both the cortex and medulla of kidney have significant differences between patients with CKD and control group. Conclusion: DKI could be a useful tool in the evaluation of renal function in children with CKD.

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