Abstract #3906

Renal [1-13C]-acetate turnover mapping with hyperpolarized MRI

Emmeli F. R. Mikkelsen¹, Thomas S. Nørlinger¹, Haiyun Qi¹, Ulrich Koellisch², Rolf F. Schulte³, Michael Pedersen¹, Hans Stødkilde-Jørgensen¹, and Christoffer Laustsen¹

¹MRI Research Centre, Aarhus University Hospital, Aarhus N, Denmark, ²Institute of Medical Engineering, Technische Universität München, Munich, Germany, ³GE Global Research, Munich, Germany

Positron Emission Tomography (PET) using carbon-11 acetate has previously been used to reveal the oxidative metabolism in the kidneys. It has been found that renal carbon-11 acetate turnover measured by PET was significantly correlated with renal oxygen consumption and tubular sodium reabsorption measured by an invasive approach. Hyperpolarized MRI is an alternative method to obtain similar intracellular measures of acetate, and the aim of this study was therefore to evaluate the rate constants of hyperpolarized [1-¹³C]-acetate in rat kidneys. The intrarenal oxygen level was altered by diuretics, and measures of acetate rate constants were calculated before and after injection of furosemide.

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