Meeting Banner
Abstract #3906

Renal [1-13C]-acetate turnover mapping with hyperpolarized MRI

Emmeli F. R. Mikkelsen1, Thomas S. Nørlinger1, Haiyun Qi1, Ulrich Koellisch2, Rolf F. Schulte3, Michael Pedersen1, Hans Stødkilde-Jørgensen1, and Christoffer Laustsen1

1MRI Research Centre, Aarhus University Hospital, Aarhus N, Denmark, 2Institute of Medical Engineering, Technische Universität München, Munich, Germany, 3GE Global Research, Munich, Germany

Positron Emission Tomography (PET) using carbon-11 acetate has previously been used to reveal the oxidative metabolism in the kidneys. It has been found that renal carbon-11 acetate turnover measured by PET was significantly correlated with renal oxygen consumption and tubular sodium reabsorption measured by an invasive approach. Hyperpolarized MRI is an alternative method to obtain similar intracellular measures of acetate, and the aim of this study was therefore to evaluate the rate constants of hyperpolarized [1-13C]-acetate in rat kidneys. The intrarenal oxygen level was altered by diuretics, and measures of acetate rate constants were calculated before and after injection of furosemide.

This abstract and the presentation materials are available to members only; a login is required.

Join Here