Abstract #3905

Renal Ischemia/Reperfusion necrosis monitoring with hyperpolarized fumarate

Per Mose Nielsen¹, Abubakr Eldirdiri², Lotte Bonde Bertelsen¹, Haiyun Qi¹, Hans Stødkilde Jørgensen¹, Jan Henrik Ardenkjaer-larsen², and Christoffer Laustsen¹

¹institute of clinical medicine, Aarhus C, Denmark, ²Lyngby, Denmark

Renal I/R-I is a leading cause of AKI in several disease states; there is a current lack of precise methods to directly assess cortical tubular injury. In the present study, we investigated the in situ conversion of fumarate to malate in a unilateral Ischemia/reperfusion model, which is correlated with renal tubular necrosis. We saw a strong binary [1,4-13C2]malate signal in the I/R-I kidney and a strong binary [1,4-13C2]fumarate signal in the healthy CL kidney. This was correlated with histological examinations indication renal tubular necrosis. As well as compartmentalized fumarase activity specific for I/R-I.

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