Abstract #3904

Quantitative Estimation of Renal Blood PO2 using BOLD MRI in Rat Kidneys.

Jon Thacker¹, Jeff Zhang², Tammy Franklin³, and Pottumarthi Prasad³

¹Northwestern University, Evanston, IL, United States, ²University of Utah, Salt Lake City, UT, United States, ³NorthShore University HealthSystem, Evanston, IL, United States

Blood oxygen level dependent (BOLD) MRI measurements generally use the transverse relaxation rate, R2*, as an indirect measure of oxygenation. While it has been shown to be related to tissue PO2, and sensitive to changes in oxygenation induced by pharmaceutical maneuvers, R2* is sensitive to other physiological parameters (e.g. hydration, hematocrit, blood perfusion) and hence not a great measure of the physiologically parameters of interest. In this study, we apply a quantitative model to BOLD MRI measurements in rodent kidneys and derive regional values for hemoglobin saturation and blood PO2. The MRI derived blood PO2 measurements are in agreement with literature.

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