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Abstract #3903

Antioxidant treatment attenuates renal lactate production in diabetic nephropathy

Christoffer Laustsen1, Thomas Stockholm Nørlinger1, Haiyun Qi1, Per Mose Nielsen1, Jakob Appel Østergaard2,3, Allan Flyvbjerg2, Jan Henrik Ardenkjaer-Larsen4, Fredrik Palm5, and Hans Stødkilde Jørgensen1

1Department of Clinical Medicine, MR-Research Centre, Aarhus University, Aarhus, Denmark, 2Department of Endocrinology and Internal Medicine and Department of Clinical Medicine, Aarhus University, Aarhus, Denmark, 3The Danish Diabetes Academy, Odense, Denmark, 4Department of Electrical Engineering, Technical University of Denmark, Kgs Lyngby, Denmark, 5Department of Medical Cell Biology, Uppsala University, Uppsala, Sweden

Early diabetic nephropathy (DN) disease progression is notoriously difficult to detect and quantify before substantial histological damage has occurred. Recently, hyperpolarized [1-13C]pyruvate has demonstrated increased lactate production, implying increased lactate dehydrogenase activity, in the kidney early after the onset of diabetes as a consequence of increased nicotinamide adenine dinucleotide (NADH) substrate availability due to elevated flux through the polyol pathway. Here we investigated whether this deranged metabolic profile can be reversed by antioxidant treatment targeting the pseudohypoxic condition.

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