Abstract #3903

Antioxidant treatment attenuates renal lactate production in diabetic nephropathy

Christoffer Laustsen¹, Thomas Stockholm Nørlinger¹, Haiyun Qi¹, Per Mose Nielsen¹, Jakob Appel Østergaard^2,3, Allan Flyvbjerg², Jan Henrik Ardenkjaer-Larsen⁴, Fredrik Palm⁵, and Hans Stødkilde Jørgensen¹

¹Department of Clinical Medicine, MR-Research Centre, Aarhus University, Aarhus, Denmark, ²Department of Endocrinology and Internal Medicine and Department of Clinical Medicine, Aarhus University, Aarhus, Denmark, ³The Danish Diabetes Academy, Odense, Denmark, ⁴Department of Electrical Engineering, Technical University of Denmark, Kgs Lyngby, Denmark, ⁵Department of Medical Cell Biology, Uppsala University, Uppsala, Sweden

Early diabetic nephropathy (DN) disease progression is notoriously difficult to detect and quantify before substantial histological damage has occurred. Recently, hyperpolarized [1-¹³C]pyruvate has demonstrated increased lactate production, implying increased lactate dehydrogenase activity, in the kidney early after the onset of diabetes as a consequence of increased nicotinamide adenine dinucleotide (NADH) substrate availability due to elevated flux through the polyol pathway. Here we investigated whether this deranged metabolic profile can be reversed by antioxidant treatment targeting the pseudohypoxic condition.

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