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Abstract #3902

Lactate dehydrogenase activity, a novel renal cortical imaging bio-marker of tubular injury.

Per Mose Nielsen1, Christoffer Laustsen1, Haiyun Qi1, Thomas Nørlinger1, Emmeli Mikkelsen1, Rikke Nørregaard1, and Hans Stødkilde Jørgensen1

1institute of clinical medicine, Aarhus C, Denmark

Renal I/R-I is a leading cause of AKI in several disease states; there is a current lack of precise methods to directly assess cortical tubular injury. In the present study, we investigated the in situ alterations of metabolic conversion of pyruvate to lactate in a unilateral I/R-I rat model using [1-13C]pyruvate magnetic resonance. A significantly reduced lactate-to-pyruvate ratio of 25% as compared to control was found in the I/R-I kidney, concomitant with a reduced LDH activity, which was specific for the I/R-I kidney. The lowered lactate-to-pyruvate ratio and LDH activity strongly correlated with general tissue damage.

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