Abstract #3901

Renal ischemia and reperfusion assessment with 3D hyperpolarized 13C urea

Per Mose Nielsen¹, Esben Søvsø Szocska Hansen², Thomas Nørlinger³, Rikke Nørregaard³, Lotte Bonde Bertelsen⁴, Hans Stødkilde Jørgensen⁵, and Christoffer Laustsen³

¹Clinical medicine, Aarhus university, Aarhus C, Denmark, ²MR Research Centre, institute of clinical medicine, Aarhus C, Denmark, ³Institute of clinical medicine, Aarhus C, Denmark, ⁴institute of clinical medicine, Aarhus C, Denmark, ⁵MR Research Centre, Institute of clinical medicine, Aarhus C, Denmark

Renal homeostasis is determined by the active transport of water and waste products, and the key to this is the active intra-renal transport of ions, creating the needed osmotic gradient. The maintenance of this cortico-medullary ion gradient is believed to be a measurement of kidney function. We investigated 3D hyperpolarized ¹³C,¹⁵N-urea for mapping of this intra-renal gradient in a unilateral ischemic reperfusion renal rat model. A 3D balanced steady state sequence with an isotropic 1.25 mm resolution was used to image renal ischemic reperfusion injury. We revealed a significant reduction in the intra-renal ion gradient in the ischemic kidney.

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