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Abstract #3901

Renal ischemia and reperfusion assessment with 3D hyperpolarized 13C urea

Per Mose Nielsen1, Esben Søvsø Szocska Hansen2, Thomas Nørlinger3, Rikke Nørregaard3, Lotte Bonde Bertelsen4, Hans Stødkilde Jørgensen5, and Christoffer Laustsen3

1Clinical medicine, Aarhus university, Aarhus C, Denmark, 2MR Research Centre, institute of clinical medicine, Aarhus C, Denmark, 3Institute of clinical medicine, Aarhus C, Denmark, 4institute of clinical medicine, Aarhus C, Denmark, 5MR Research Centre, Institute of clinical medicine, Aarhus C, Denmark

Renal homeostasis is determined by the active transport of water and waste products, and the key to this is the active intra-renal transport of ions, creating the needed osmotic gradient. The maintenance of this cortico-medullary ion gradient is believed to be a measurement of kidney function. We investigated 3D hyperpolarized 13C,15N-urea for mapping of this intra-renal gradient in a unilateral ischemic reperfusion renal rat model. A 3D balanced steady state sequence with an isotropic 1.25 mm resolution was used to image renal ischemic reperfusion injury. We revealed a significant reduction in the intra-renal ion gradient in the ischemic kidney.

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