Abstract #3908

Effect of a two week hyper energetic matched high carbohydrate vs high fat diet on hepatic fat stores and metabolic blood markers: A 1H MRS Study

Stephen Bawden^1,2, Carolyn Chee³, Peter Mansell³, Francis Stephens³, Sally Cordon³, Mehri Kaviani², Caroline Hoad², Luca Marciani¹, Penny Gowland², Guruprasad Aithal¹, and Ian Macdonald³

¹NIHR Nottingham Digestive Diseases Research Unit, University of Nottingham, Nottingham, United Kingdom, ²Sir Peter Mansfield Imaging Centre, University of Nottingham, Nottingham, United Kingdom, ³School of Life Sciences, University of Nottingham, Nottingham, United Kingdom

This study used ¹H MRS to investigate the effects of a two week hyper-energetic 25% excess overfeeding diet of either high carbohydrate or high fat content on liver fat in 20 healthy overweight volunteers. Significant increases were found in whole group and in the high carbohydrate group, with smaller non-significant increases observed in the high fat group. Other blood measures and body fat were investigated also.

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