Stephen Bawden1,2, Carolyn Chee3, Peter Mansell3, Francis Stephens3, Sally Cordon3, Mehri Kaviani2, Caroline Hoad2, Luca Marciani1, Penny Gowland2, Guruprasad Aithal1, and Ian Macdonald3
1NIHR Nottingham Digestive Diseases Research Unit, University of Nottingham, Nottingham, United Kingdom, 2Sir Peter Mansfield Imaging Centre, University of Nottingham, Nottingham, United Kingdom, 3School of Life Sciences, University of Nottingham, Nottingham, United Kingdom
This study used 1H MRS to investigate the effects of a two week hyper-energetic 25% excess overfeeding diet of either high carbohydrate or high fat content on liver fat in 20 healthy overweight volunteers. Significant increases were found in whole group and in the high carbohydrate group, with smaller non-significant increases observed in the high fat group. Other blood measures and body fat were investigated also.