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Abstract #3909

Effects of lifestyle intervention on liver volume, intrahepatic fat and body weight:  What are the metabolic benefits?

Malte Niklas Bongers1, Norbert Stefan2, Andreas Fritsche2, Claus Claussen1, Hans-Ulrich Häring2, Konstantin Nikolaou1, Fritz Schick3, and Jürgen Machann3,4,5

1Department of Diagnostic and Interventional Radiology, University Hospital of Tübingen, Tübingen, Germany, 2Department of Endocrinology, Metabolism, Clinical Chemistry, Nephrology and Angiology, University Hospital of Tübingen, Tübingen, Germany, 3Department of Diagnostic and Interventional Radiology, Section on Experimental Radiology, University Hospital of Tübingen, Tübingen, Germany, 4Institute for Diabetes Research and Metabolic Diseases (IDM) of the Helmholtz Center Munich at the University of Tübingen (Paul Langerhans Institute Tübingen), Tübingen, Germany, 5German Center for Diabetes Research (DZD), Tübingen, Germany

Using MRI, the quantification of liver volume and identification of several compartments of adipose tissue with varying impact on metabolism is reliably possible. 1H-MRS is established as non-invasive ‘gold standard’ to quantify the amount of ectopic lipids in the liver. Lifestyle interventions show differing effects on the compartments of physiological and ectopic lipids. Caloric restriction during lifestyle interventions leads to reduced liver volume, caused by a decrease of intrahepatic lipids (IHL). The decrease of IHL shows gender specific effects on liver enzymes, primarily resulting in lowered gamma-glutamyl transferase in females and lowered alanine transaminase in males. Only in females, the decrease of IHL seems to influence the systemic low-grade inflammation positively.

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