Abstract #3920

Infant size-for-gestational age, obesity and ethnicity are associated with intramyocellular lipid content in Asian preschoolers

Navin Michael¹, Suresh Anand Sadananthan¹, Mya Thway Tint², Kuan Jin Lee³, Jay Jay Thaung Zaw², Khin Thu Zar Hlaing², Pang Wei Wei², Lynette Pei-Chi Shek⁴, Yap Kok Peng Fabian^5,6, Peter D. Gluckman^1,7, Keith M. Godfrey⁸, Yap Seng Chong^1,2, Melvin Khee-Shing Leow^9,10, Yung Seng Lee^1,4, Christiani Jeyakumar Henry⁹, Marielle Valerie Fortier¹¹, and S. Sendhil Velan^1,3

¹Singapore Institute for Clinical Sciences, A*STAR, Singapore, ²Department of Obstetrics & Gynaecology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, ³Singapore BioImaging Consortium, A*STAR, Singapore, ⁴Department of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, ⁵Department of Paediatric Endocrinology, KK Women’s and Children’s Hospital, Singapore, ⁶Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, ⁷Liggins Institute, University of Auckland, Auckland, New Zealand, ⁸MRC Lifecourse Epidemiology Unit & NIHR Southampton Biomedical Research Centre, University of Southampton & University Hospital Southampton NHS Foundation Trust, Southampton, United Kingdom, ⁹Clinical Nutrition Research Centre, Singapore Institute for Clinical Sciences, A*STAR, Singapore, ¹⁰Department of Endocrinology, Tan Tock Seng Hospital, Singapore, ¹¹Department of Diagnostic and Interventional Imaging, KK Women’s and Children’s Hospital, Singapore

The goal of this study was to understand the contribution of ethnicity, obesity and early developmental factors on IMCL determined in Asian preschoolers. Prior works on IMCL in children have found IMCL to be positively associated with childhood obesity and maternal hyperglycemia. We show that, while children with higher BMI-for-age have higher IMCL, children born SGA also have higher IMCL at 4.5 years, despite being less obese, and despite having lower maternal BMI and maternal fasting glucose than children born AGA. We also found higher IMCL in 4.5 year-old Indian children than in Chinese and Malay children.

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