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Abstract #3920

Infant size-for-gestational age, obesity and ethnicity are associated with intramyocellular lipid content in Asian preschoolers

Navin Michael1, Suresh Anand Sadananthan1, Mya Thway Tint2, Kuan Jin Lee3, Jay Jay Thaung Zaw2, Khin Thu Zar Hlaing2, Pang Wei Wei2, Lynette Pei-Chi Shek4, Yap Kok Peng Fabian5,6, Peter D. Gluckman1,7, Keith M. Godfrey8, Yap Seng Chong1,2, Melvin Khee-Shing Leow9,10, Yung Seng Lee1,4, Christiani Jeyakumar Henry9, Marielle Valerie Fortier11, and S. Sendhil Velan1,3

1Singapore Institute for Clinical Sciences, A*STAR, Singapore, 2Department of Obstetrics & Gynaecology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 3Singapore BioImaging Consortium, A*STAR, Singapore, 4Department of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 5Department of Paediatric Endocrinology, KK Women’s and Children’s Hospital, Singapore, 6Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, 7Liggins Institute, University of Auckland, Auckland, New Zealand, 8MRC Lifecourse Epidemiology Unit & NIHR Southampton Biomedical Research Centre, University of Southampton & University Hospital Southampton NHS Foundation Trust, Southampton, United Kingdom, 9Clinical Nutrition Research Centre, Singapore Institute for Clinical Sciences, A*STAR, Singapore, 10Department of Endocrinology, Tan Tock Seng Hospital, Singapore, 11Department of Diagnostic and Interventional Imaging, KK Women’s and Children’s Hospital, Singapore

The goal of this study was to understand the contribution of ethnicity, obesity and early developmental factors on IMCL determined in Asian preschoolers. Prior works on IMCL in children have found IMCL to be positively associated with childhood obesity and maternal hyperglycemia. We show that, while children with higher BMI-for-age have higher IMCL, children born SGA also have higher IMCL at 4.5 years, despite being less obese, and despite having lower maternal BMI and maternal fasting glucose than children born AGA. We also found higher IMCL in 4.5 year-old Indian children than in Chinese and Malay children.

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