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Abstract #3921

Comparison of abdominal fat volume and fat cell hypertrophy in ex-SGA and AGA Asian preschoolers

Suresh Anand Sadananthan1, Navin Michael1, Mya Thway Tint2, Kuan Jin Lee3, Jay Jay Thaung Zaw2, Khin Thu Zar Hlaing2, Pang Wei Wei2, Lynette Pei-Chi Shek4, Yap Kok Peng Fabian5,6, Peter D. Gluckman1,7, Keith M. Godfrey8, Yap Seng Chong1,2, Melvin Khee-Shing Leow9,10, Yung Seng Lee1,4, Christiani Jeyakumar Henry9, Marielle Valerie Fortier11, and S. Sendhil Velan1,3

1Singapore Institute for Clinical Sciences, A*STAR, Singapore, 2Department of Obstetrics & Gynaecology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 3Singapore BioImaging Consortium, A*STAR, Singapore, 4Department of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 5Department of Paediatric Endocrinology, KK Women’s and Children’s Hospital, Singapore, 6Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, 7Liggins Institute, University of Auckland, Auckland, New Zealand, 8MRC Lifecourse Epidemiology Unit & NIHR Southampton Biomedical Research Centre, University of Southampton & University Hospital Southampton NHS Foundation Trust, Southampton, United Kingdom, 9Clinical Nutrition Research Centre, Singapore Institute for Clinical Sciences, A*STAR, Singapore, 10Department of Endocrinology, Tan Tock Seng Hospital, Singapore, 11Department of Diagnostic and Interventional Imaging, KK Women’s and Children’s Hospital, Singapore

Children born small-for-gestational age (SGA) are at an increased risk of developing diabetes and obesity. In vitro studies have shown higher lipid content in adipocytes differentiated from mesenchymal stem cells obtained from the umbilical cord of SGA neonates compared to appropriate-for-gestational age (AGA) infants. However, validating this in children is difficult as assessment of adipocyte hypertrophy has traditionally necessitated adipose tissue biopsies. In earlier studies, we have shown that hydrolipidic ratio (HLR) determined using MRS is negatively associated with adipocyte hypertrophy. In this work, we examined the size-for-gestational age specific differences in abdominal subcutaneous fat and HLR in Asian preschoolers.

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