Abstract #3921

Comparison of abdominal fat volume and fat cell hypertrophy in ex-SGA and AGA Asian preschoolers

Suresh Anand Sadananthan¹, Navin Michael¹, Mya Thway Tint², Kuan Jin Lee³, Jay Jay Thaung Zaw², Khin Thu Zar Hlaing², Pang Wei Wei², Lynette Pei-Chi Shek⁴, Yap Kok Peng Fabian^5,6, Peter D. Gluckman^1,7, Keith M. Godfrey⁸, Yap Seng Chong^1,2, Melvin Khee-Shing Leow^9,10, Yung Seng Lee^1,4, Christiani Jeyakumar Henry⁹, Marielle Valerie Fortier¹¹, and S. Sendhil Velan^1,3

¹Singapore Institute for Clinical Sciences, A*STAR, Singapore, ²Department of Obstetrics & Gynaecology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, ³Singapore BioImaging Consortium, A*STAR, Singapore, ⁴Department of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, ⁵Department of Paediatric Endocrinology, KK Women’s and Children’s Hospital, Singapore, ⁶Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, ⁷Liggins Institute, University of Auckland, Auckland, New Zealand, ⁸MRC Lifecourse Epidemiology Unit & NIHR Southampton Biomedical Research Centre, University of Southampton & University Hospital Southampton NHS Foundation Trust, Southampton, United Kingdom, ⁹Clinical Nutrition Research Centre, Singapore Institute for Clinical Sciences, A*STAR, Singapore, ¹⁰Department of Endocrinology, Tan Tock Seng Hospital, Singapore, ¹¹Department of Diagnostic and Interventional Imaging, KK Women’s and Children’s Hospital, Singapore

Children born small-for-gestational age (SGA) are at an increased risk of developing diabetes and obesity. In vitro studies have shown higher lipid content in adipocytes differentiated from mesenchymal stem cells obtained from the umbilical cord of SGA neonates compared to appropriate-for-gestational age (AGA) infants. However, validating this in children is difficult as assessment of adipocyte hypertrophy has traditionally necessitated adipose tissue biopsies. In earlier studies, we have shown that hydrolipidic ratio (HLR) determined using MRS is negatively associated with adipocyte hypertrophy. In this work, we examined the size-for-gestational age specific differences in abdominal subcutaneous fat and HLR in Asian preschoolers.

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