Abstract #3923

Longitudinal and Cross-Sectional Assessment of Proton Density Fat Fraction and Metabolic Syndrome in Obese Patients undergoing Weight Loss Surgery

Curtis N. Wiens¹, Alan B. McMillan¹, Nathan S. Artz^1,2, William Haufe³, Camilo A. Campo¹, Alexandria Schlein³, Luke Funk⁴, Jacob Greenberg⁴, Guilherme M. Campos⁵, Claude Sirlin³, and Scott B. Reeder^1,6,7,8,9

¹Radiology, University of Wisconsin, Madison, WI, United States, ²Diagnostic Imaging, St. Jude Children's Research Hospital, Memphis, TN, United States, ³Radiology, University of California, San Diego, CA, United States, ⁴Surgery, University of Wisconsin, Madison, WI, United States, ⁵Surgery, Virginia Commonwealth University, Richmond, VA, United States, ⁶Medical Physics, University of Wisconsin, Madison, WI, United States, ⁷Biomedical Engineering, University of Wisconsin, Madison, WI, United States, ⁸Medicine, University of Wisconsin, Madison, WI, United States, ⁹Emergency Medicine, University of Wisconsin, Madison, WI, United States

The purpose of this work was to determine the relationship between proton density fat fraction (PDFF) and metabolic syndrome (MetS) in obese patients. Patients were recruited for an MRI study 1-2 days prior to weight loss surgery (WLS). A subset of these patients with biopsy confirmed hepatic steatosis were recruited for a second MRI 6 months post WLS. A cut-off PDFF of 7.5% had a sensitivity of 77% and specificity of 80% for predicting MetS prior to undergoing WLS. At 6 months follow-up, patients with confirmed hepatic steatosis had significantly decreased prevalence of MetS (91% to 52%). Additionally, other metabolic, biometric, and imaging (PDFF) markers related to MetS were significantly reduced.

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