Abstract #3926

Quantitative Magnetic Resonance Imaging of Renal Steatosis in Obesity and Type II Diabetes Mellitus

Haley R Clark¹, Ivan Pedrosa^1,2, Ildiko Lingvay^3,4, Muhammad Beg³, Ion A Bobulescu³, and Takeshi Yokoo^1,2

¹Radiology, University of Texas Southwestern Medical Center, Dallas, TX, United States, ²Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, TX, United States, ³Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, United States, ⁴Clinical Science, University of Texas Southwestern Medical Center, Dallas, TX, United States

In this retrospective pilot study, proton-density fat fraction (PDFF) of kidneys was compared in 40 and 29 adult subjects without and with type 2 diabetes mellitus (DM2), respectively. Median PDFF was significantly higher in DM2 (2.18%) than non-DM2 subjects (0.78%), with p=0.0008. Statistically significant correlation was found between renal PDFF and body-mass-index (BMI; r=0.2661, p=0.027). After correcting for age, sex, and BMI, PDFF difference due to DM2 remained statistically significant with p=0.0045.

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