Abstract #3925

Longitudinal imaging of interscapular brown adipose tissues in high fat diet induced obese rats

Jadegoud Yaligar¹, Sanjay Kumar Verma¹, Bhanu Prakash KN¹, Tian Xianfeng¹, Venkatesh Gopalan¹, Swee Shean Lee¹, Suresh Anand Sadananthan², Navin Michael², Ong Wee Kiat³, Shigeki Sugii ³, and S Sendhil Velan¹

¹Laboratory of Metabolic Imaging, Singapore Bioimaging Consortium, A*STAR, Singapore, ²Singapore Institute for Clinical Sciences, A*STAR, Singapore, ³Fat Metabolism and Stem Cell Group, Singapore Bioimaging Consortium, A*STAR, Singapore

Obesity and diabetes are major metabolic disorders associated with dietary intake. Brown adipose tissue (BAT) is major site for adaptive thermogenesis involving uncoupling protein-1. We performed longitudinal imaging of fat fraction (FF) of interscapular BAT in control and high fat diet fed rats under thermoneutral and cold exposure conditions on Wistar rats of 7, 11 and 15 weeks. High fat diet results in increased fat fraction in iBAT. Histology shows increased size of brown adipocytes which may alter BAT function and influence thermogenic potential. UCP1 was upregulated in HFD groups. With cold exposure FF reduced significantly in control and HFD groups.

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