Abstract #3931

Imaging of Dermal White Adipose Tissue in Mice

Diego Hernando¹, Ildiko Kasza², Scott B Reeder^1,3,4,5,6, and Caroline M Alexander²

¹Radiology, University of Wisconsin-Madison, Madison, WI, United States, ²McArdle Laboratory for Cancer Research, University of Wisconsin-Madison, Madison, WI, United States, ³Medical Physics, University of Wisconsin-Madison, Madison, WI, United States, ⁴Biomedical Engineering, University of Wisconsin-Madison, Madison, WI, United States, ⁵Medicine, University of Wisconsin-Madison, Madison, WI, United States, ⁶Emergency Medicine, University of Wisconsin-Madison, Madison, WI, United States

Dermal white adipose tissue (DWAT) has only recently been recognized as a distinct adipocyte depot, with the potential to influence metabolism and physiology. In this study, we introduce a fat-water MRI approach for noninvasive quantification of the DWAT layer in mice on a clinical 3T scanner, and validate this approach using histology. As shown by MRI and histology, DWAT is thinner in Sdc1-/- mice compared to wild type. Interestingly, DWAT was dramatically thicker in an obese mouse model.

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