Abstract #3941

Fast PCr Imaging of Rat Calf Muscles Using Spiral-In/Out bSSFP

Yuchi Liu¹, Yun Jiang¹, Charlie Yi Wang¹, Mark Alan Griswold^1,2, and Xin Yu^1,2,3,4

¹Biomedical Engineering, Case Western Reserve University, Cleveland, OH, United States, ²Radiology, Case Western Reserve University, Cleveland, OH, United States, ³Physiology and Biophysics, Case Western Reserve University, Cleveland, OH, United States, ⁴Case Center for Imaging Research, Case Western Reserve University, Cleveland, OH, United States

In this study, a fast phosphocreatine (PCr) imaging method was developed by combining spectrally selective bSSFP with single-shot spiral-in/out encoding for measuring PCr distribution in vivo. 2 min acquisition yielded an SNR of ~9 in rat calf muscles with high spatial resolution (1.25 mm×1.25 mm×5 mm) at 9.4T. The SNR was increased to 25.5 with 30 min acquisition. This method also has the potential for imaging other metabolites such as ATP with a different carrier frequency, dynamic PCr imaging in exercise-recovery or ischemia-reperfusion studies, and quantification of the absolute metabolite concentration with appropriate T₁, T₂, and flip angle calibration/correction.

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