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Abstract #3942

Sensitivity Comparison of Ultrahigh-field Oxygen-17 MRS Imaging between 7T and 10.5T using a Human Head Size Phantom and Quadrature Surface Coil

Hannes Michel Wiesner1, Xiao-Hong Zhu1, Kamil Ugurbil1, and Wei Chen1

1CMRR, Radiology, University of Minnesota Medical School, Minneapolis, MN, United States

In vivo 17O MRS imaging provides a valuable tool for quantitatively imaging the cerebral rate of oxygen metabolism, cerebral blood flow and oxygen extraction fraction from a brief inhalation of 17O-isotope labeled oxygen gas. In this study, we conducted a pilot test to examine the 17O sensitivity using the human head size water phantom in the world's first 10.5T whole-body human scanner at the CMRR, then compared it with that at 7T. We found approximately doubled 17O sensitivity at 10.5T after careful consideration signal and noise contributions at both fields.

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